Melanotan II

What is Melanotan II?

Melanotan II is a synthetic peptide designed to mimic the natural hormone α-MSH. It has been extensively studied for its impact on melanogenesis (skin pigmentation), sexual behavior, and appetite suppression. Research indicates that MT-2 acts on multiple melanocortin receptors, offering insights into a variety of physiological and neurological functions. It is provided in lyophilized powder form for research applications and is not intended for human or veterinary use.

Structure

Chemical formula: C50H69N15O9

Melanotan II is a cyclic heptapeptide that contains a lactam bridge and functions as a non-selective agonist of melanocortin receptors, enhancing stability and receptor affinity in experimental conditions.

Melanotan II Research

Melanotan II and Melanocortin Signaling

Melanotan II is a key research peptide for studying the melanocortin system, particularly MC1R through MC5R. Studies suggest MT-2 enhances melanogenesis by binding to MC1R on melanocytes, stimulating the production of eumelanin. Additionally, its effects on MC3R and MC4R are being explored for their influence on energy balance, sexual function, and behavior. MT-2 continues to provide a valuable platform for understanding how melanocortin signaling affects systemic physiology in preclinical models.

Melanotan II and Autism

Some animal studies have suggested that melanocortin receptor activity could influence social and behavioral patterns associated with autism spectrum disorder (ASD). MT-2 has been investigated for its effects on repetitive behaviors and social interaction in rodent models. Early research indicates a potential role in modulating neuropeptides linked to behavior and stress, though these findings remain preliminary and require further investigation to establish translational relevance.

Melanotan II and Hunger

Melanotan II has demonstrated appetite-suppressing effects in rodent models, particularly through its action on the MC4R receptor. Research indicates that MT-2 may reduce food intake and increase energy expenditure by influencing central pathways involved in hunger and satiety. These findings make MT-2 an important compound in the study of obesity, metabolic disorders, and appetite regulation at the molecular level.

Melanotan II and Diabetes

Preclinical trials have explored MT-2’s ability to improve insulin sensitivity and reduce body weight in diabetic models. Its effects on glucose metabolism may be attributed to interactions with MC4R, which is known to play a role in energy homeostasis. Although MT-2 is not a therapeutic agent, research is ongoing to evaluate its implications in understanding and potentially addressing metabolic dysfunction in diabetes.

Melanotan II, Impulse Control and Alcohol Intake

Studies have investigated the role of Melanotan II in regulating impulsive behaviors, including alcohol consumption. MT-2 appears to modulate dopaminergic pathways associated with reward and compulsion, making it a potential research compound in studies focused on addiction and self-regulation. Its influence on MC4R may be key in altering neural circuits related to impulse control and substance use.

Melanotan II and Erectile Dysfunction

Melanotan II has shown promise in animal models for its ability to induce spontaneous erections by activating the MC3R and MC4R receptors in the central nervous system. These studies suggest a mechanism independent of traditional nitric oxide pathways, making MT-2 a novel compound for investigating sexual function and potential non-hormonal treatments for erectile dysfunction in research settings.

Future MT-2 Research

Emerging research is expanding MT-2’s profile into areas such as mood regulation, neuroinflammation, and neurodegenerative conditions. Scientists are particularly interested in its potential to influence brain-derived neurotrophic factors (BDNF), inflammation markers, and behavioral adaptations. As understanding of the melanocortin system grows, Melanotan II remains a critical tool in mapping physiological and psychological processes tied to receptor signaling.

Disclaimer

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.