SLU-PP-332

What is SLU-PP-332?

SLU-PP-332 is a synthetic compound designed to activate estrogen-related receptors (ERRs), particularly ERRα. These nuclear receptors are involved in regulating metabolic pathways, including mitochondrial biogenesis and energy metabolism. By modulating ERR activity, SLU-PP-332 has been investigated for its potential to mimic exercise-induced metabolic benefits, such as increased fatty acid oxidation and improved endurance. This compound is intended solely for scientific investigation and is not approved for human or veterinary use.

Structure

• Chemical Formula: C₁₈H₁₄N₂O₂
• Synonyms: 4-hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide

SLU-PP-332 Research

SLU-PP-332 and Mitochondrial Function

In vitro studies have demonstrated that SLU-PP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. Treatment with SLU-PP-332 increased the expression of pyruvate dehydrogenase kinase 4 (Pdk4), a target gene of ERRs involved in energy metabolism. Additionally, it boosted mitochondrial respiration in C2C12 myocytes, indicating a potential role in improving cellular energy production. 

SLU-PP-332 and Exercise Endurance

Animal studies have explored the impact of SLU-PP-332 on physical performance. In mice, administration of SLU-PP-332 increased the proportion of oxidative (Type IIa) muscle fibers and enhanced exercise endurance. These findings suggest that SLU-PP-332 may mimic certain adaptations associated with endurance training, potentially offering insights into muscle physiology and performance enhancement. 

SLU-PP-332 and Metabolic Health

Research involving diet-induced obese mice has investigated the metabolic effects of SLU-PP-332. Treatment with the compound led to increased energy expenditure and fatty acid oxidation, resulting in reduced fat mass accumulation. Furthermore, SLU-PP-332 improved insulin sensitivity in models of metabolic syndrome, indicating potential applications in studying metabolic disorders such as obesity and type 2 diabetes. 

Disclaimer

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Referenced Citations

1. Billon C, Murray MH, Avdagic A, et al. “Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Metabolic Gene Signature and Enhances Exercise Capacity.” ACS Chemical Biology. 2023;18(4):839–849. Available at: https://pubmed.ncbi.nlm.nih.gov/36988910/ 

2. Billon C, Murray MH, Avdagic A, et al. “A Synthetic ERR Agonist Alleviates Metabolic Syndrome.” Journal of Pharmacology and Experimental Therapeutics. 2024;379(3):301–312. Available at: https://pubmed.ncbi.nlm.nih.gov/37739806/