Semax

Research Overview of Semax

Molecular Structure and Background

Semax is a synthetic peptide analog of ACTH (4-10) that omits corticostimulatory effects but retains neuroactive properties. Its structure—Met-Glu-His-Phe-Pro-Gly-Pro—is designed to resist enzymatic degradation and enhance stability during neurochemical research protocols [1]. According to PubChem (CID: 9941956), Semax is of interest for studies related to neuromodulation, neuroprotection, and peptide-receptor interactions.

Neuroplasticity and Brain Function Research

One of the primary areas of research for Semax is its potential influence on brain-derived neurotrophic factor (BDNF) and related pathways. Studies in rodent models have shown that Semax administration can modulate gene expression involved in synaptic plasticity and neurogenesis [1]. Research has also focused on its impact on cognitive performance and learning capacity under stress or chemically-induced brain dysfunction.

Stress Response and Hypoxia Studies

Semax has been included in research evaluating adaptive mechanisms to oxidative stress and hypoxia in animal models. Investigators have studied its impact on the expression of antioxidative enzymes and regulatory proteins in conditions of reduced oxygen availability. These studies focus on cellular defense systems and mitochondrial signaling [1].

Neuroinflammation and Ischemia Models

Additional preclinical work has utilized Semax in ischemic stroke models to investigate its effect on inflammatory cytokine profiles, endothelial markers, and blood-brain barrier integrity [1]. These models are strictly experimental and designed to assess peptide behavior in extreme CNS stress scenarios.

Peptide Transport and Enzymatic Stability

Semax’s resistance to proteolytic degradation has made it useful in peptide stability and translocation studies, particularly in assessing nasal-to-brain delivery routes. These findings are significant in academic research focused on bioavailability of neuroactive peptides in animal models [1].

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THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Referenced Citations

1. PubChem Compound Summary for CID 9941956, Semax.
   Source: PubChem