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5-Amino-1MQ is a small molecule derivative of 1-methylquinolinium. It has garnered research interest due to its interaction with cellular energy pathways, particularly its potential modulation of nicotinamide N-methyltransferase (NNMT) activity. This compound is strictly for in vitro or in vivo research use in controlled laboratory environments.
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5-Amino-1MQ is a synthetic small molecule belonging to the quinolinium compound class. Structurally, it is a substituted quinolinium salt bearing a methyl group at the 1-position and an amino group at the 5-position. According to the PubChem database (CID: 91827313), it has been studied primarily for its role in the regulation of nicotinamide N-methyltransferase (NNMT)—an enzyme involved in NAD+ metabolism and methylation pathways [1].
NNMT catalyzes the methylation of nicotinamide, influencing cellular energy balance and methyl group availability. 5-Amino-1MQ has been researched for its ability to inhibit NNMT, thereby potentially impacting cellular bioenergetics and S-adenosylmethionine (SAM) utilization [1].
In preclinical models, NNMT inhibition by 5-Amino-1MQ has been observed to influence adipocyte metabolism. One study found that suppression of NNMT activity with 5-Amino-1MQ altered the expression of genes related to oxidative phosphorylation and mitochondrial activity [1]. The compound has been used in murine studies to investigate mechanisms of energy expenditure regulation under controlled research settings.
Although not studied for therapeutic purposes, 5-Amino-1MQ has been included in research exploring metabolic dysregulation. Laboratory-based murine studies have used the compound to investigate the biochemical impact of NNMT inhibition on adipose tissue inflammation, insulin resistance, and NAD+ salvage pathway integrity [1].
NNMT expression is known to be elevated in several cancer cell lines, and 5-Amino-1MQ has been explored in vitro as a chemical probe to assess the role of NNMT in cellular proliferation, migration, and epigenetic modulation [1]. These applications are strictly limited to laboratory research and are not intended for human use.
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THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
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