DSIP

What is DSIP?

DSIP is a nonapeptide composed of the amino acids Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It is present in various regions of the central nervous system and peripheral tissues. Although originally linked to sleep induction, its exact biological functions are still under investigation. Research shows DSIP may influence circadian rhythm, act as an endocrine modulator, and have neuroprotective properties [1][2]. This compound is intended strictly for scientific research and is not approved for human or veterinary use.

Structure

• Molecular Formula: C35H48N10O15
• Synonyms: DSIP

DSIP Research

1. DSIP and Sleep Modulation

DSIP has long been studied for its involvement in sleep regulation. Clinical research in chronic insomniacs has shown that DSIP administration increases sleep efficiency and decreases sleep latency [1]. These results support DSIP’s role as a neuromodulator potentially useful in managing sleep disorders.

2. DSIP as an Anticonvulsant

In animal models, DSIP has been shown to reduce the frequency and severity of chemically induced seizures [2]. The peptide is believed to interact with GABAergic systems, suggesting a potential mechanism for its anticonvulsant effects, and making it an area of interest in epilepsy research.

3. DSIP in Neuroprotection and Stroke Recovery

In a rat stroke model, DSIP significantly improved motor recovery and reduced neurological deficits [3]. This neuroprotective effect is believed to be related to its anti-inflammatory and anti-apoptotic properties, indicating a promising role in neurorehabilitation studies.

4. DSIP and Endocrine Regulation

DSIP is known to influence pituitary hormone secretion. It has been shown to stimulate luteinizing hormone (LH) release and suppress corticotropin levels, pointing to a regulatory role in both the stress response and reproductive systems [4].

5. DSIP and Stress Modulation

Experimental models show that DSIP administration counteracts stress-induced changes in physiological markers, including blood pressure and corticosterone levels [4]. This suggests DSIP may act as a stress-limiting peptide with potential relevance in stress-related research.

Disclaimer

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Referenced Citations

1. Effects of delta sleep-inducing peptide on sleep of chronic insomniacs. PubMed. Available at: https://pubmed.ncbi.nlm.nih.gov/1299794/ 

2. Studies of the mechanism of the anticonvulsant effect of delta-sleep-inducing peptide. SpringerLink. Available at: https://link.springer.com/article/10.1007/BF02461934 

3. Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats After Stroke. MDPI. Available at: https://www.mdpi.com/1420-3049/26/17/5173 

4. Delta-sleep-inducing peptide. Wikipedia. Available at: https://en.wikipedia.org/wiki/Delta-sleep-inducing_peptide