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Ipamorelin is a selective pentapeptide agonist of the growth hormone secretagogue receptor (GHSR), formula C₃₈H₄₉N₉O₅, PubChem CID 9831659. It is widely used to study pituitary GH release mechanisms and receptor-binding selectivity.
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Ipamorelin activates GHSR in pituitary cells to induce GH secretion, providing a controlled model to study GH-releasing pathways, receptor binding kinetics, and signal amplification [1] [2].
By isolating GH/IGF-1-mediated metabolic effects, ipamorelin is used to explore selective endocrine stimulation without affecting ACTH or cortisol release, supporting research in receptor specificity [2].
It is utilized alongside GHRP-6 and other secretagogues to compare potency, selectivity, and desensitization kinetics [2].
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