KLOW

Research Application

1. Cellular Repair and Regeneration

KLOW includes BPC-157, a pentadecapeptide derived from gastric proteins, and TB-500, a thymosin β4 fragment. Both are widely used in preclinical models to promote fibroblast migration, tissue remodeling, and angiogenesis. In murine wound and tendon injury models, these peptides accelerate cellular outgrowth, extracellular matrix formation, and vascularization [1] [2].

GHK-Cu, a naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine), is studied for its regulatory effects on wound healing, skin regeneration, and tissue remodeling, often attributed to its ability to upregulate metalloproteinases and suppress oxidative damage [3].

2. Anti-Inflammatory and Immune Modulation

KPV, a C-terminal tripeptide fragment of alpha-MSH (Lys-Pro-Val), is included for its potent anti-inflammatory properties. It has been shown in rodent colitis and dermatitis models to reduce TNF-α, IL-6, and NF-κB expression, indicating suppression of key inflammatory cascades [4].

Together with BPC-157—also known to modulate inflammatory cytokine activity—KLOW is suited for research involving immune response modulation and epithelial barrier integrity under inflammatory stress.

3. Angiogenesis and Microvascular Studies

Both TB-500 and BPC-157 are associated with enhanced angiogenesis and improved microcirculation in ischemic tissue. GHK-Cu contributes by stimulating VEGF production and endothelial cell proliferation. These effects have been documented in cardiovascular and dermal injury models, supporting their use in vascular and perfusion-based research [5].

This makes KLOW applicable in experimental studies on endothelial function, ischemic damage, and post-injury vascular remodeling.

4. Epithelial Barrier and Gut Models

In gut-related research, KPV and BPC-157 have shown protective effects in models of intestinal inflammation and permeability disruption. KPV exerts action through melanocortin receptor pathways, while BPC-157 supports tight junction integrity. This combination allows KLOW to be used in advanced GI, epithelial barrier, and microbiome interaction studies [6].

Referenced Citations

1. Sikiric P, et al. “BPC 157 and organ/tissue healing mechanisms.” PubMed
   Source: Regulatory Peptides – Tissue regeneration and inflammation studies.
2. Goldstein AL, et al. “Thymosin beta-4 and tissue repair.” PubMed
   Source: Annals of the New York Academy of Sciences – Role in cell migration and repair.
3. Pickart L, et al. “GHK-Cu peptide regulation of gene expression.” PubMed
   Source: BioMed Research International – Skin and gene regulation effects.
4. Getting SJ. “KPV peptide in inflammation models.” PubMed
   Source: European Journal of Pharmacology – Cytokine modulation and inflammation control.
5. Strandjord TP, et al. “GHK and copper peptide signaling in angiogenesis.” PubMed
   Source: Journal of Investigative Dermatology – VEGF stimulation by GHK-Cu.
6. Mounsey KE, et al. “Anti-inflammatory mechanisms of KPV.” PubMed
   Source: Peptides – MC1R-mediated anti-inflammatory effects.

Disclaimer

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. THIS PRODUCT IS INTENDED FOR RESEARCH PURPOSES ONLY AND IS NOT INTENDED FOR HUMAN CONSUMPTION.