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KPV (Lys-Pro-Val) is a tripeptide fragment (residues 11-13) of alpha-melanocyte-stimulating hormone (α-MSH) with molecular formula C₁₆H₃₀N₄O₄. It is studied for its anti-inflammatory and epithelial transport characteristics in intestinal and dermal research models.
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KPV has been shown to reduce intestinal inflammation through PepT1-mediated uptake, decreasing cytokine release and neutrophil infiltration. It is often used to study intestinal epithelial barrier regulation and transporter-mediated peptide absorption [1] [2].
This tripeptide is employed in dermal studies to explore its effects on keratinocyte activity, fibroblast migration, and the modulation of NF-κB and TNF-α pathways. It provides insights into peptide-mediated regulation of cutaneous inflammation and wound-repair mechanisms [2].
KPV’s small molecular size allows detailed study of PepT1 transporter kinetics and targeted peptide delivery under inflammatory conditions in cell cultures [2].
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