Livagen (Bioregulator)

Research Overview

1. Structure and Molecular Characteristics

Livagen is a synthetic peptide composed of lysine, glutamic acid, aspartic acid, and proline. Its molecular formula is C₁₈H₃₂N₆O₉, with a molecular weight of 474.45 g/mol [1]. As a member of the family of bioregulatory peptides, Livagen is structurally simple but exhibits high biological activity in experimental systems, particularly those involving hepatic cells [1].

2. Hepatic and Metabolic Research

Livagen has been extensively studied in hepatocyte culture systems, where it demonstrated regulatory effects on cell proliferation and differentiation [2]. Experimental studies show that it can modulate activity of genes involved in metabolic regulation, detoxification, and protein biosynthesis [3].

Research has also suggested that Livagen influences the synthesis of albumin and other plasma proteins in cultured hepatocytes [2]. Since liver tissue plays a central role in metabolism and detoxification, Livagen is a key tool in studies exploring peptide-mediated regulation of hepatic function.

3. Gene Expression and Epigenetic Regulation

Beyond direct metabolic effects, Livagen has been shown to regulate gene expression at the epigenetic level. Experimental evidence suggests that it modulates histone acetylation and methylation patterns in liver cells [4]. This makes Livagen particularly interesting for research into how short peptides can influence chromatin structure and transcriptional activity.

In addition, studies have indicated that Livagen affects the activity of DNA repair enzymes and transcription factors, pointing to a broader role in genomic stability [4].

4. Aging and Gerontology Research

Livagen has been employed in gerontology studies to examine age-associated decline in hepatocyte function [5]. Findings indicate that it supports maintenance of protein synthesis and detoxification capacity in senescent liver models, suggesting it plays a role in age-related cellular regulation. This has made Livagen a consistent focus in experimental biogerontology [5].

5. Broader Research Applications

Although most research has focused on hepatic systems, Livagen has also been investigated in models of general metabolism, cell cycle regulation, and oxidative stress [3][4]. Its activity across multiple cellular pathways positions it as a useful peptide for systems-level studies in peptide biology.

Referenced Citations

1. PubChem. Livagen. CID 11845109. PubChem
2. Khavinson VKh, et al. Peptide regulation of hepatocyte proliferation and differentiation. Bull Exp Biol Med. 2002. PubMed
3. Khavinson VKh, et al. Short peptides and regulation of liver metabolic activity. Bull Exp Biol Med. 2003. PubMed
4. Khavinson VKh, et al. Epigenetic modulation by peptide Livagen in hepatocyte models. Bull Exp Biol Med. 2005. PubMed
5. Khavinson VKh, et al. Livagen effects on protein synthesis in senescent liver tissue. Bull Exp Biol Med. 2007. PubMed

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