Prostamax

Research Overview

1. Structure and Molecular Characteristics

Prostamax is a short synthetic peptide consisting of lysine, glutamic acid, aspartic acid, and proline. Its molecular formula is C₁₈H₃₂N₆O₉, with a molecular weight of 474.45 g/mol [1]. As part of the bioregulatory peptide class, Prostamax demonstrates high biological specificity in experimental prostate cell models while retaining structural simplicity [1].

2. Prostate Tissue Research

Prostamax has been investigated for its ability to regulate the function of prostate epithelial cells and fibroblasts [2]. In culture systems, it promoted proliferative and metabolic activity in both young and senescent cells. Unlike individual amino acids, which often show diminished impact in aged tissues, Prostamax maintained efficacy across models [2].

Studies also indicate that Prostamax influences extracellular matrix composition by regulating collagen and elastin synthesis in prostate tissues, suggesting its involvement in structural homeostasis [3].

3. Fibroblast and Cellular Differentiation Studies

Fibroblasts play a key role in maintaining prostate structure and function. Research has shown that Prostamax upregulates expression of signaling molecules such as CXCL12, WEDC1, and ghrelin in aging fibroblasts [4]. These molecules are central to fibroblast differentiation, extracellular signaling, and stromal-epithelial interactions. Prostamax’s ability to restore diminished expression of these factors highlights its potential as a research tool for prostate aging biology [4].

4. Gene Expression and Molecular Mechanisms

Prostamax has been shown to modulate expression of structural and nuclear proteins, including actin, tubulin, vimentin, and lamins A/C [5]. These proteins are essential for cytoskeletal stability and nuclear integrity. Experimental findings also suggest that Prostamax influences gene transcription associated with cellular metabolism, oxidative stress responses, and DNA repair mechanisms [5].

5. Aging and Senescence Research

Prostamax is frequently studied in the context of gerontology. Findings demonstrate that it supports cellular activity in senescent prostate models by maintaining protein synthesis and extracellular signaling pathways [2][4]. This makes it relevant for experimental research on age-related prostate decline and cellular senescence more broadly.

Referenced Citations

1. PubChem. Prostamax. CID 9947840. PubChem
2. Khavinson VKh, et al. Regulatory effects of short peptides on prostate epithelial cells in aging models. Bull Exp Biol Med. 2004. PubMed
3. Khavinson VKh, et al. Prostamax modulation of extracellular matrix proteins in prostate tissue. Bull Exp Biol Med. 2005. PubMed
4. Khavinson VKh, et al. Restoration of signaling factor expression in aging fibroblasts by Prostamax. Bull Exp Biol Med. 2006. PubMed
5. Khavinson VKh, et al. Gene expression regulation by tetrapeptide Prostamax in prostate fibroblasts. Bull Exp Biol Med. 2007. PubMed

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