Semaglutide

What is Semaglutide?

Semaglutide is a synthetic analogue of the human GLP-1 hormone, designed to bind and activate the GLP-1 receptor. This activation promotes glucose-dependent insulin secretion and inhibits glucagon release, aiding in blood sugar regulation. Additionally, semaglutide slows gastric emptying, leading to increased satiety and potential weight loss. Due to its extended half-life, semaglutide is administered once weekly, offering a convenient dosing regimen for research purposes. This compound is intended solely for scientific investigation and is not approved for human or veterinary use.

Structure

• Chemical Formula: C₁₈₇H₂₉₁N₄₅O₅₉
• Synonyms: NN9535, Ozempic, Rybelsus, Wegovy

Semaglutide Research

Semaglutide in Type 2 Diabetes Management

Clinical trials have demonstrated that semaglutide significantly improves glycemic control in individuals with type 2 diabetes. In the SUSTAIN-6 trial, semaglutide reduced HbA1c levels and was associated with a lower rate of major adverse cardiovascular events compared to placebo. These findings suggest its potential role in comprehensive diabetes management. [1]

Semaglutide and Weight Management

Research indicates that semaglutide may be effective in promoting weight loss among individuals with obesity. A study published in The New England Journal of Medicine reported that participants receiving semaglutide experienced significant weight reduction compared to those on placebo. This effect is attributed to its action on appetite regulation and energy intake. [2]

Cardiovascular Outcomes with Semaglutide

Semaglutide has been evaluated for its impact on cardiovascular outcomes in patients with type 2 diabetes. The SUSTAIN-6 trial demonstrated a significant reduction in the risk of major adverse cardiovascular events among participants treated with semaglutide. These results highlight its potential cardiovascular benefits beyond glycemic control. [3]

Semaglutide and Non-Alcoholic Steatohepatitis (NASH)

Emerging studies suggest that semaglutide may have therapeutic potential in treating non-alcoholic steatohepatitis (NASH). Clinical trials have shown improvements in liver enzyme levels and reductions in liver fat content among patients with NASH treated with semaglutide, indicating a possible role in managing this condition. [4]

Disclaimer

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Referenced Citations

1. Marso SP, Daniels GH, Brown-Frandsen K, et al. “Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.” The New England Journal of Medicine. 2016;375(19):1834–1844. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa1607141 

2. Wilding JPH, Batterham RL, Calanna S, et al. “Once-Weekly Semaglutide in Adults with Overweight or Obesity.” The New England Journal of Medicine. 2021;384(11):989–1002. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 

3. Marso SP, Bain SC, Consoli A, et al. “Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.” The New England Journal of Medicine. 2016;375(19):1834–1844. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa1607141 

4. Newsome PN, Buchholtz K, Cusi K, et al. “A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis.” The New England Journal of Medicine. 2021;384(12):1113–1124. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa2028395