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Sermorelin

Sermorelin

Sermorelin is a synthetic analogue of human GHRH(1-29)-amide, formula C₁₄₉H₂₄₆N₄₄O₄₂S, PubChem CID 16132413. It is used in laboratory studies of pituitary GH secretion, hypothalamic-pituitary feedback, and endocrine signaling.

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Research Applications

  1. Pituitary GHRH Receptor Studies

Sermorelin mimics endogenous GHRH, stimulating GH release from anterior pituitary cells, allowing study of receptor binding and desensitization processes [1] [2].

  1. Endocrine Feedback Models

It is employed to study GH-IGF-1 feedback loops and somatostatin-mediated suppression, offering insight into age-related declines in GH responsiveness [2].

  1. Downstream GH/IGF-1 Pathway Research

Sermorelin-induced GH release enables exploration of tissue-specific gene activation and IGF-1 synthesis in experimental systems [2].

Referenced Citations

  1. PubChem Compound Summary for CID 16132413 — Sermorelin
  2. Sermorelin: Pharmacologic Review — PubMed PMID 18031173

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