Vesugen

Research Overview

1. Structure and Molecular Characteristics

Vesugen is a synthetic tetrapeptide consisting of lysine, glutamic acid, aspartic acid, and proline. Its molecular formula is C₁₈H₃₂N₆O₉, with a molecular weight of 474.45 g/mol [1]. Belonging to the class of short bioregulatory peptides, Vesugen demonstrates high tissue specificity in experimental models of vascular and endothelial regulation [1].

2. Vascular and Endothelial Research

Vesugen has been studied for its ability to modulate endothelial cell proliferation and differentiation [2]. In animal models, the peptide demonstrated activity in supporting endothelial repair and regulation of vascular tone. Unlike single amino acids, Vesugen retained activity in aged vascular tissues, suggesting unique peptide-mediated effects [2].

Additionally, Vesugen influences smooth muscle cells within blood vessels, helping regulate contractility and supporting vessel wall stability in preclinical models [3].

3. Extracellular Matrix and Structural Protein Studies

Vesugen has been shown to regulate the synthesis of collagen and elastin in vascular tissues [3]. These proteins are essential for vascular elasticity and resilience. In fibroblast and endothelial cultures, Vesugen also influenced cytoskeletal proteins such as actin, tubulin, and vimentin, highlighting its role in structural integrity and cell signaling [4].

4. Gene Expression and Molecular Mechanisms

Experimental data suggest that Vesugen modulates gene expression related to angiogenesis, oxidative stress response, and mitochondrial activity [5]. This includes upregulation of growth factors and transcription factors essential for vascular remodeling. These findings make Vesugen a valuable research tool for understanding peptide-mediated regulation of vascular gene networks [5].

5. Aging and Gerontology Research

In gerontology studies, Vesugen has been used to investigate age-associated decline in vascular function. Findings show that it maintains endothelial proliferation and extracellular matrix regulation in senescent vascular tissues [6]. This supports its relevance for experimental research into vascular aging and the molecular biology of senescence.

Referenced Citations

1. PubChem. Vesugen. CID 9947854. PubChem
2. Khavinson VKh, et al. Regulatory effects of vascular peptide Vesugen on endothelial proliferation. Bull Exp Biol Med. 2004. PubMed
3. Khavinson VKh, et al. Vesugen modulation of smooth muscle activity and extracellular matrix synthesis. Bull Exp Biol Med. 2005. PubMed
4. Khavinson VKh, et al. Short peptide regulation of cytoskeletal proteins in vascular fibroblasts. Bull Exp Biol Med. 2006. PubMed
5. Khavinson VKh, et al. Gene expression modulation in vascular cells by Vesugen. Bull Exp Biol Med. 2007. PubMed
6. Khavinson VKh, et al. Vesugen effects on vascular aging in experimental models. Bull Exp Biol Med. 2008. PubMed

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