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Bronchogen (H-Glu-Asp-Ala-OH) is a synthetic tripeptide, molecular weight ~291.27 Da (PubChem CID: 23678447). Classified as a short bioregulatory peptide, it has been studied in experimental models for its ability to regulate bronchial epithelial cell activity, gene expression, and extracellular signaling in respiratory research contexts.
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Bronchogen is a tripeptide consisting of glutamic acid, aspartic acid, and alanine. Its molecular formula is C₁₀H₁₇N₃O₈, with a molecular weight of 291.27 g/mol [1]. As a member of the class of synthetic short peptides, it is polar, water-soluble, and capable of interacting with cellular and nuclear proteins in respiratory tissue models [1].
Bronchogen has been investigated in preclinical studies for its role in regulating the function of bronchial epithelial cells [2]. Research in aged and young animal models indicates that the peptide enhances proliferative and metabolic activity of these cells [2]. Unlike individual amino acids, which often show diminished activity in senescent cells, Bronchogen maintained consistent regulatory properties across different age groups, making it relevant for experimental studies into age-related respiratory decline [2].
In bronchial epithelial cell cultures, Bronchogen has been shown to influence gene expression associated with protein synthesis, cellular metabolism, and extracellular signaling [3]. These include modulation of genes involved in structural proteins and enzymatic pathways. Such effects suggest its potential importance as a tool for research into peptide-mediated regulation of bronchial tissue biology [3].
Experimental evidence suggests that Bronchogen influences structural protein expression, particularly cytoskeletal proteins like actin, tubulin, and vimentin [4]. These proteins contribute to cellular morphology, mechanical stability, and intracellular transport. Bronchogen’s ability to modulate these factors supports further studies into how synthetic peptides regulate fibroblast activity in respiratory tissues [4].
Bronchogen is also a subject of gerontology-focused studies. Investigations into aging respiratory systems demonstrate that the peptide may restore diminished signaling pathways and maintain cellular activity despite senescence [2][5]. This property has made it of interest in experimental biology, particularly for understanding peptide influences on age-related changes in bronchial tissue.
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