Bronchogen (Bioregulator)

Research Overview

1. Structure and Molecular Characteristics

Bronchogen is a tripeptide consisting of glutamic acid, aspartic acid, and alanine. Its molecular formula is C₁₀H₁₇N₃O₈, with a molecular weight of 291.27 g/mol [1]. As a member of the class of synthetic short peptides, it is polar, water-soluble, and capable of interacting with cellular and nuclear proteins in respiratory tissue models [1].

2. Respiratory Research

Bronchogen has been investigated in preclinical studies for its role in regulating the function of bronchial epithelial cells [2]. Research in aged and young animal models indicates that the peptide enhances proliferative and metabolic activity of these cells [2]. Unlike individual amino acids, which often show diminished activity in senescent cells, Bronchogen maintained consistent regulatory properties across different age groups, making it relevant for experimental studies into age-related respiratory decline [2].

3. Gene Expression Studies

In bronchial epithelial cell cultures, Bronchogen has been shown to influence gene expression associated with protein synthesis, cellular metabolism, and extracellular signaling [3]. These include modulation of genes involved in structural proteins and enzymatic pathways. Such effects suggest its potential importance as a tool for research into peptide-mediated regulation of bronchial tissue biology [3].

4. Fibroblast and Cytoskeletal Regulation

Experimental evidence suggests that Bronchogen influences structural protein expression, particularly cytoskeletal proteins like actin, tubulin, and vimentin [4]. These proteins contribute to cellular morphology, mechanical stability, and intracellular transport. Bronchogen’s ability to modulate these factors supports further studies into how synthetic peptides regulate fibroblast activity in respiratory tissues [4].

5. Aging and Cellular Senescence Research

Bronchogen is also a subject of gerontology-focused studies. Investigations into aging respiratory systems demonstrate that the peptide may restore diminished signaling pathways and maintain cellular activity despite senescence [2][5]. This property has made it of interest in experimental biology, particularly for understanding peptide influences on age-related changes in bronchial tissue.

Referenced Citations

1. PubChem. Bronchogen. CID 23678447. PubChem
2. Khavinson VKh, et al. Effect of short peptides on proliferation of bronchial epithelial cells in aging models. Bull Exp Biol Med. 2004. PubMed
3. Khavinson VKh, et al. Short peptides regulate gene expression in bronchial epithelial cells. Bull Exp Biol Med. 2005. PubMed
4. Khavinson VKh, et al. Bronchogen modulation of cytoskeletal protein synthesis in respiratory fibroblasts. Bull Exp Biol Med. 2006. PubMed
5. Khavinson VKh, et al. Peptide regulation of age-related decline in bronchial epithelial cells. Bull Exp Biol Med. 2007. PubMed

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