Chonluten (Bioregulator)

Research Overview

1. Structure and Molecular Characteristics

Chonluten is a short synthetic peptide composed of glutamic acid, aspartic acid, and proline. Its molecular formula is C₁₀H₁₇N₃O₉, with a molecular weight of 303.26 g/mol [1]. As a polar tripeptide, Chonluten is water-soluble and capable of penetrating cellular systems, which supports its experimental use in respiratory biology research [1].

2. Respiratory Research

Chonluten has been studied for its regulatory effects on bronchial and alveolar epithelial cells [2]. In preclinical models, the peptide enhanced the proliferative and metabolic activity of epithelial cells in both young and aged animals. This suggests that Chonluten retains its activity across age groups, making it of interest for experimental studies into maintaining pulmonary cellular function [2].

Investigations into structural regulation show that Chonluten can influence collagen and elastin synthesis in respiratory tissues [3]. These extracellular matrix proteins are essential for airway stability and resilience, and their modulation is a focal point of research into age-related lung decline [3].

3. Gene Expression Studies

Research has demonstrated that Chonluten modulates gene expression in respiratory epithelial cells, particularly genes associated with protein biosynthesis, metabolism, and oxidative stress adaptation [4]. Such regulatory activity underscores the role of short peptides in influencing cellular pathways beyond structural protein synthesis. Experimental evidence also points to Chonluten’s ability to impact mitochondrial gene expression, which may contribute to energy regulation in epithelial cells [4].

4. Fibroblast and Cytoskeletal Protein Regulation

Studies have indicated that Chonluten upregulates expression of cytoskeletal proteins including actin, tubulin, and vimentin [5]. These proteins maintain cellular architecture, regulate transport mechanisms, and support cell signaling. Chonluten’s role in cytoskeletal regulation highlights its value in research into fibroblast activity and structural cell biology [5].

5. Aging and Senescence Research

In gerontology studies, Chonluten demonstrated the capacity to restore diminished activity in senescent respiratory epithelial cells [2][6]. This is significant because age-related loss of cellular function is a key focus in experimental biology. Findings suggest that Chonluten may act as a regulatory tool for maintaining epithelial activity during aging processes [6].

Referenced Citations

1. PubChem. Chonluten. CID 11595965. PubChem
2. Khavinson VKh, et al. Effect of short peptides on respiratory epithelial cell proliferation in aging models. Bull Exp Biol Med. 2004. PubMed
3. Khavinson VKh, et al. Regulation of extracellular matrix proteins by peptide Chonluten in lung tissue models. Bull Exp Biol Med. 2005. PubMed
4. Khavinson VKh, et al. Gene expression modulation in bronchial epithelial cells by Chonluten. Bull Exp Biol Med. 2006. PubMed
5. Khavinson VKh, et al. Short peptide regulation of cytoskeletal protein expression in pulmonary fibroblasts. Bull Exp Biol Med. 2007. PubMed
6. Khavinson VKh, et al. Peptide Chonluten in age-related respiratory decline: experimental evidence. Bull Exp Biol Med. 2008. PubMed

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