SLU-PP-332

SLU-PP-332 is a potent ERR agonist advancing research into metabolic regulation, exercise-mimetic pathways, mitochondrial health, and cardiovascular function. With demonstrated effects in multiple preclinical models, it provides a versatile platform for exploring the molecular underpinnings of energy metabolism and mitochondrial biology.[1]

Research Applications

1. Metabolic Regulation and Obesity Models

In mouse studies, SLU-PP-332 significantly reduced weight gain and fat accumulation in diet-induced obesity models. Treated animals displayed improved glucose tolerance and insulin sensitivity, highlighting its potential as a research tool in energy metabolism and obesity mechanisms.[5]

2. Exercise-Mimetic Research

Administration of SLU-PP-332 increased endurance in sedentary rodents, with studies reporting up to 70% longer running times and improved mitochondrial density.[6] This supports its use in research investigating exercise physiology and pharmacological exercise mimetics.

3. Mitochondrial Function and Aging

Studies show SLU-PP-332 reverses mitochondrial dysfunction in aged tissues, reduces oxidative stress, and restores autophagy and mitophagy processes.[7] These findings position it as a valuable compound for research into cellular aging, mitochondrial dynamics, and oxidative metabolism.

4. Cardiovascular Research

Preclinical data suggest SLU-PP-332 improves cardiac contractility, reduces fibrosis, and preserves energetic balance in heart failure models.⁸ These effects underscore its importance in research on cardiac energetics and myocardial resilience.

Referenced Citations

1. Bio-Techne. SLU-PP-332 Product Overview. Bio-Techne
2. PubChem. 4-Hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide. PubChem
3. Wikipedia. SLU-PP-332. Wikipedia
4. PMC. Pan-ERR Agonism and Metabolic Regulation. PubMed Central
5. PMC. SLU-PP-332 in Diet-Induced Obesity Models. PubMed Central
6. University of Florida News. Exercise-Mimicking Drug Discovery. UF News
7. Wikipedia. SLU-PP-332 Research Applications. Wikipedia
8. PMC. ERR Agonists and Cardiac Function Studies. PubMed Central

Disclaimer

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. THIS PRODUCT IS INTENDED FOR RESEARCH PURPOSES ONLY AND IS NOT INTENDED FOR HUMAN CONSUMPTION.