Tesamorelin

What is Tesamorelin?

Tesamorelin is a stabilized GHRH analog consisting of 44 amino acids, developed to extend the biological half-life of natural GHRH. It selectively binds to pituitary receptors to increase the synthesis and release of growth hormone, without influencing other hormonal systems. Tesamorelin is utilized in research models to study lipodystrophy, fat redistribution, neuroregeneration, and metabolic conditions. It is not indicated for human or animal use and is intended solely for scientific investigation.

Structure

Chemical Formula: C221H366N72O67S1

Tesamorelin is a synthetic peptide that mimics GHRH with a modified N-terminal structure to improve stability and receptor affinity, preserving its potency and extending its biological half-life in experimental environments.

Tesamorelin Research

Tesamorelin and Lipodystrophy

Tesamorelin has been extensively studied for its potential to reduce excess visceral fat in HIV-associated lipodystrophy. It promotes endogenous growth hormone secretion, which in turn stimulates lipolysis and reduces abdominal fat accumulation. Research shows Tesamorelin may also preserve lean body mass while improving metabolic markers such as triglyceride levels. These characteristics make it a significant compound in metabolic and endocrinological research related to abnormal fat distribution.

Tesamorelin Investigated in Cardiac Disease

Recent studies have explored Tesamorelin’s role in improving cardiovascular health, particularly among patients with increased abdominal fat. It has been shown to reduce pericardial fat volume, a factor linked with cardiac inflammation and risk. In some trials, Tesamorelin also positively influenced cholesterol ratios and inflammatory markers, suggesting its relevance in cardiovascular risk assessment and mitigation strategies under controlled experimental conditions.

Growth Hormone Deficiency and HIV

Tesamorelin is being used in research to assess the long-term impacts of growth hormone deficiency in individuals with HIV. By enhancing natural GH release, it may help address metabolic disturbances often seen in HIV-positive populations, including insulin resistance and muscle wasting. Its targeted activity makes it valuable in studying endocrine function and anabolic processes without the side effects of direct GH administration.

Tesamorelin for Peripheral Nerve Damage

Preclinical investigations have highlighted Tesamorelin’s potential role in peripheral nerve regeneration. Through its stimulation of IGF-1 and GH pathways, Tesamorelin may support Schwann cell activity, axonal growth, and myelin repair. These neurotrophic effects are being studied for their therapeutic potential in models of nerve trauma and neurodegenerative conditions.

Tesamorelin Investigated in Dementia

Emerging research has begun to examine Tesamorelin’s effects on cognitive function and brain health. By increasing IGF-1, a growth factor implicated in neuroprotection, Tesamorelin is being evaluated for its influence on hippocampal function, memory, and synaptic plasticity. Though still in early stages, these studies suggest a potential role for Tesamorelin in dementia-related research, particularly Alzheimer’s disease.

Disclaimer

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.